Known for her confessional lyrics and raspy, smoky vocals, Melissa Etheridge has remained one of America's favorite female singers for more than two decades. She stormed onto the American rock scene in 1988 with the release of her critically acclaimed self-titled debut album. Her popularity grew around hits like "Bring Me Some Water," "No Souvenirs" and "Ain't It Heavy," for which she won a Grammy in 1992. Etheridge hit her commercial and artistic stride with her fourth album, Yes I Am (1993). The collection featured the massive hits, "I'm the Only One" and "Come to My Window." In 1995, Etheridge issued her highest charting album, Your Little Secret, which was distinguished by the hit single, "I Want to Come Over."

In 2007, Melissa Etheridge won an Oscar for "I Need to Wake Up," written for the Al Gore documentary on global warming, An Inconvenient Truth. As a performer and songwriter, Etheridge has shown herself to be an artist who has never allowed "inconvenient truths" to keep her down. Earlier in her recording career, Etheridge acknowledged her sexual orientation when it was considered less than prudent to do so. In October 2004, Etheridge was diagnosed with breast cancer, a health battle that, with her typical tenacity, she won. Despite losing her hair from chemotherapy, Etheridge appeared on the 2005 Grammy telecast to sing "Piece of My Heart" in tribute to Janis Joplin. By doing so she gave hope to many women afflicted with the disease.   

In June of 2020, Etheridge launched The Etheridge Foundation to support groundbreaking scientific research into effective new treatments for opioid use disorder. The Foundation works towards advancing treatment approaches that address the root causes of opioid abuse and make available better, more effective solutions for people to truly heal their opioid use disorder.